Diminished effector and memory CD8+ circulating T lymphocytes in patients with severe influenza caused by the AH1N1 pdm09 virus
نویسندگان
چکیده
منابع مشابه
An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells.
Influenza A virus infection of C57BL/6 (B6) mice is characterized by prominent CD8(+) T cell responses to H2D(b) complexed with peptides from the viral nucleoprotein (NP(366), ASNENMETM) and acid polymerase (PA(224), SSLENFRAYV). An in vivo cytotoxicity assay that depends on the adoptive transfer of peptide-pulsed, syngeneic targets was used in this study to quantitate the cytotoxic potential o...
متن کاملAntigenic Variation of the Haemagglutinin Gene of the Influenza A (H1N1) pdm09 Virus Circulating in Shiraz, February-April 2013
Background: A new pandemic influenza A (H1N1) emerged in April 2009, causing considerable morbidity and mortality. Since mutations in the haemagglutinin (HA) may influence the antigenicity and pathogenicity of the virus, continued epidemiological and molecular characterization for the effective control of pandemic flu and developing of more appropriate vaccine is crucial. Objective: To monitor ...
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چکیده ندارد.
Effector memory T lymphocytes in renal disease.
RECENT STUDIES HAVE DEMONSTRATED that the immune system plays an important pathophysiological role in diseases of the kidney and the vasculature. In particular, the role of T lymphocytes in the development and maintenance of renal (1, 3, 4, 5) and cardiovascular disease (3, 5, 6, 9) has been a topic of intense study in recent years. Pharmacological and genetic methods in experimental animals ha...
متن کاملCD4+/CD8+ T lymphocytes imbalance in children with severe 2009 pandemic influenza A (H1N1) pneumonia
PURPOSE This study was conducted to investigate the immune responses of children with moderate and severe novel influenza A virus (H1N1) pneumonia, and to compare their clinical and immunological findings with those of control subjects. METHODS Thirty-two admitted patients with H1N1 pneumonia were enrolled in the study. The clinical profiles, humoral and cell-mediated immune responses of the ...
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ژورنال
عنوان ژورنال: Virology
سال: 2017
ISSN: 0042-6822
DOI: 10.1016/j.virol.2016.10.016